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A02: Context effects on threat processing in dependence of testosterone levels

The focus will be on the influences of a provocative context on social threat processing in AMD under different testosterone levels. Specifically, the project aims to analyze the modulating function of context under testosterone application versus suppression on threat sensitivity in healthy controls as well as patient groups. Additionally, we will determine the influence of endogenous hormone variations (testosterone, oxytocin, estrogen and cortisol) on NVS in high versus low aggressive patients in a large group of patients recruited in Q01. With this sample, we will try to identify multidimensional biosignatures based on hormonal levels in combination with fMRI measures of amygdala and amygdala-prefrontal connectivity, NVS measures by questionnaires, aggression measures and psychopathological data.

Katja Bertsch

A02: Context effects on threat processing in dependence of testosterone levels B04: Investigating psychological and neural correlates of intimate partner violence Principal investigator Julius-Maximilians University Würzburg

Katja Bertsch is a Professor for Clinical Psychology and Psychotherapy at the Julius-Maximilians-University Würzburg.

Ute Habel

A02: Context effects on threat processing in dependence of testosterone levels A04: Implicit chemosensory threat signals as stimulators of amygdala hyperresponsiveness in AMD Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span Q04: Central coordination Principal investigator Spokesperson RWTH Aachen Research Center Jülich (FZJ)

Professor Ute Habel is a distinguished academic at RWTH Aachen University, renowned for her expertise in neuropsychology.

Sabine Herpertz

A02: Context effects on threat processing in dependence of testosterone levels C06: Brain mechanisms differentiating aggressive vs. non-aggressive psychopathology as sequelae of early life maltreatment Q01: Recruitment and biotyping transdiagnostic risk mechanisms for aggressive behaviors in mental disorders across the life span Principal investigator Deputy Spokesperson Goethe University Frankfurt

Prof Dr Sabine C.